Systemic treatment for hereditary cancers: a 2012 update
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Systemic treatment for hereditary cancers: a 2012 update
The history of specific therapy for hereditary tumors dates back to mid 1980s and involves a number of reports demonstrating regression of familial colon polyps upon administration of sulindac. Virtually no clinical studies on other hereditary cancer types were available until the year 2009, when Byrski et al. presented the data on unprecedented sensitivity of BRCA1-associated breast malignanci...
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Tumors arising in patients with hereditary cancer syndromes may have distinct drug sensitivity as compared to their sporadic counterparts. Breast and ovarian neoplasms from BRCA1 or BRCA2 mutation carriers are characterized by deficient homologous recombination (HR) of DNA, that makes them particularly sensitive to platinum compounds or inhibitors of poly (ADP-ribose) polymerase (PARP). Outstan...
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ژورنال
عنوان ژورنال: Hereditary Cancer in Clinical Practice
سال: 2013
ISSN: 1897-4287
DOI: 10.1186/1897-4287-11-2